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Table 4 Measurable outcomes

From: Evaluation of the effects of pycnogenol (French maritime pine bark extract) supplementation on inflammatory biomarkers and nutritional and clinical status in traumatic brain injury patients in an intensive care unit: A randomized clinical trial protocol


Time frame

Measurement method

Change of inflammatory markers: IL-6 a, IL-1β b

5 and 10 days


Change of inflammatory marker: CRP c

5 and 10 days

Auto analyzer

Change of oxidative stress markers: MDA d, TAC e

5 and 10 days


Change of weight

5 and 10 days

Portable scale “Balas”

Change of body fat percentage

5 and 10 days

Bio impedance device “Inbody”

Change of body mass index

5 and 10 days


Change of APCHE ІІ f score

5 and 10 days

APCHEІІ score questionnaire

Change of SOFA g score

3, 5, 7, 9, 10 day

SOFA score questionnaire

Change of NUTRIC score

5 and 10 days

NUTRIC score questionnaire

28-day mortality

28 days

Telephone follow-up

  1. a Interleukin-6. b Interleukin-1β. c C-reactive protein. d Malondialdehyde. e Total antioxidant capacity f Acute physiologic and chronic health evaluation II. g Sequential organ failure assessment
  2. *Colorimetry is a scientific technique that is used to determine the concentration of colored compounds in solutions by the application of the Beer–Lambert law, which states that the concentration of a solute is proportional to the absorbance