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Table 2 Overview of study procedures

From: INtervention for Cognitive Reserve Enhancement in delaying the onset of Alzheimer’s Symptomatic Expression (INCREASE), a randomized controlled trial: rationale, study design, and protocol

Procedure Screening Baseline cognitive testing Month 3 Month 6 Month 9 End-of-study cognitive testing
Scopolamine challenged Non-challenged Scopolamine challenged Non-challenged
Study week −5 ± 2 weeks − 4 ± 1 0 ± 1 13 ± 1 26 ± 1 39 ± 1 52 ± 1 56 ± 1
Demographics X        
Health history X X X X X X X X
Medication review X X X X X X X X
NAART X        
TMTB   X X     X X
CVLT   X X     X X
MoCA   X X     X X
SF-36 X        X
ECG X        
Physical exam X        X
Neurological exam X        X
Gait and balance X X    X   X X
Aβ-PET imaging X        
MTM intervention    X   X   X  
Telephone follow-up     X   X   
  1. NAART North American Adult Reading Test, TMTB Trail Making Test B, CVLT California Verbal Learning Test, MoCA Montreal Cognitive Assessment, SF-36 Short-Form 36, ECG electrocardiogram,  amyloid beta, PET positron emission tomography, MTM medication therapy management