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Table 2 Overview of study procedures

From: INtervention for Cognitive Reserve Enhancement in delaying the onset of Alzheimer’s Symptomatic Expression (INCREASE), a randomized controlled trial: rationale, study design, and protocol

Procedure

Screening

Baseline cognitive testing

Month 3

Month 6

Month 9

End-of-study cognitive testing

Scopolamine challenged

Non-challenged

Scopolamine challenged

Non-challenged

Study week

−5 ± 2 weeks

− 4 ± 1

0 ± 1

13 ± 1

26 ± 1

39 ± 1

52 ± 1

56 ± 1

Demographics

X

       

Health history

X

X

X

X

X

X

X

X

Medication review

X

X

X

X

X

X

X

X

NAART

X

       

TMTB

 

X

X

   

X

X

CVLT

 

X

X

   

X

X

MoCA

 

X

X

   

X

X

SF-36

X

      

X

ECG

X

       

Physical exam

X

      

X

Neurological exam

X

      

X

Gait and balance

X

X

  

X

 

X

X

Aβ-PET imaging

X

       

MTM intervention

  

X

 

X

 

X

 

Telephone follow-up

   

X

 

X

  
  1. NAART North American Adult Reading Test, TMTB Trail Making Test B, CVLT California Verbal Learning Test, MoCA Montreal Cognitive Assessment, SF-36 Short-Form 36, ECG electrocardiogram, Aβ amyloid beta, PET positron emission tomography, MTM medication therapy management
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Trials

ISSN: 1745-6215