Table 1 Schedule of assessments, KARAOKE study

Informed consent

x

Knee x-ray

x

Knee MRI

x*

x

 Bloods

x

x

x

 Clinical examination

x

 Leg strength

x

x

x

 Height and weight

x

x

 Capsules given

x

x

 Capsule count

x

x

 Pressure pain testing (Melbourne/Perth only)

x

x

x

 Ultrasound (Perth)

x

x

 Knee VAS

x

x

x

x

x

x

x

x

 Knee WOMAC

x

x

x

x

x

x

x

 Knee ICOAP

x

x

x

x

x

x

x

 Patient global evaluation

x

x

x

x

x

x

x

 Joint replacement surgery

x

x

x

 Concomitant medications

x

x

x

 Safety (AEs)

x

x

 Hand VAS, back VAS

x

x

x

x

x

x

x

 AQoL

x

x

x

 Patient health questionnaire (PHQ-9)

x

 Pain at other sites

x

x

x

 Treatment guessing

x

x

 painDETECT

x

 Adverse events

 Early withdrawal