Characteristics | Placebo (n = 65) | Metoprolol (n = 65) |
---|---|---|
Demographics | ||
Age (years) | ||
Mean (SD) | 42.8 (14.3) | 44.4 (14.2) |
Median (range) | 44.0 (19–70) | 45.0 (19–75) |
Male sex | ||
n (%) | 29 (44.6) | 22 (33.8) |
VM diagnostic criteria | ||
Probable VM, n (%) | 27 (41.5) | 23 (35.4) |
Definite VM, n (%) | 38 (58.5) | 42 (64.6) |
General physical examination | ||
Body mass index (kg/m2) | ||
Mean (SD) | 26.4 (5.5) | 25.9 (3.9) |
Median (range) | 25.3 (17.6–46.6) | 26.0 (17.5–38.1) |
Missing, n (%) | 5 (7.7) | 6 (9.2) |
Systolic blood pressure (mmHg) | ||
Mean (SD) | 134.1 (18.6) | 136.8 (16.3) |
Median (range) | 130.0 (100.0–188.0) | 136.0 (109.0–180.0) |
Missing, n (%) | 9 (13.8) | 6 (9.2) |
Diastolic blood pressure (mmHg) | ||
Mean (SD) | 85.8 (10.1) | 85.5 (9.7) |
Median (range) | 86.0 (66.0–108.0) | 84.0 (68.0–107.0) |
Missing, n (%) | 9 (13.8) | 6 (9.2) |
Heart rate (bpm) | ||
Mean (SD) | 74.8 (10.0) | 72.4 (10.3) |
Median (range) | 73.0 (60.0–100.0) | 73.0 (54.0–100.0) |
Missing, n (%) | 8 (12.3) | 6 (9.2) |
DHI total scorea | ||
Mean (SD) | 1.7 (0.8) | 1.6 (0.7) |
Median (range) | 1.7 (0.4–3.5) | 1.5 (0.4–3.1) |
Missing, n (%) | 1 (1.5) | 2 (3.1) |
Physical examination | ||
Cranial nerves: head-shaking nystagmus | ||
Patients with nystagmus, n (%) | 4 (6.2) | 4 (6.2) |
Missing, n (%) | 5 (7.7) | 6 (9.2) |
Coordination: Romberg’s test | ||
Patients with instability, n (%) | 3 (4.6) | 4 (6.2) |
Missing, n (%) | 2 (3.1) | 0 (0.0) |
Neuro-orthoptic examinations | ||
Smooth pursuit eye movement | ||
Saccaded, n (%) | 25 (41.5) | 29 (44.6) |
Missing, n (%) | 2 (1.5) | 0 (0.0) |
Absolute SVV deviation (°) | ||
Mean (SD) | 0.5 (1.2) | 0.4 (1.2) |
Median (range) | 0.0 (0.0–5.0) | 0.0 (0.0–6.0) |
Missing, n (%) | 3 (4.6) | 0 (0.0) |
Gaze-evoked nystagmus | ||
n (%) | 7 (10.8) | 14 (21.5) |
Missing, n (%) | 2 (3.1) | 0 (0.0) |
Nystagmus in the scanning laser ophthalmoscope | ||
n (%) | 8 (12.3) | 3 (4.6) |
Missing, n (%) | 12 (18.5) | 9 (13.8) |
Disturbed fixation suppression | ||
n (%) | 6 (9.2) | 3 (4.6) |
Missing, n (%) | 4 (6.2) | 1 (1.5) |
Oculography | ||
Spontaneous nystagmus (°/s) | ||
Velocity = 0, n (%) | 47 (72.3) | 48 (73.8) |
Velocity ≥1, n (%) | 16 (24.5) | 16 (24.5) |
Velocity ≥3, n (%) | 1 (1.5) | 1 (1.5) |
Missing, n (%) | 2 (3.1) | 1 (1.5) |
Gaze-evoked nystagmus (°/s) | ||
Velocity = 0, n (%) | 14 (21.5) | 7 (10.8) |
Velocity ≥1, n (%) | 43 (66.1) | 49 (75.3) |
Velocity ≥3, n (%) | 6 (9.2) | 10 (15.3) |
Missing, n (%) | 8 (12.3) | 9 (13.8) |
Bithermal caloric testing (normalized right–left difference (%) according to Jongkees’ formulab) | ||
Mean (SD) | −8.5 (20.5) | −6.9 (21.9) |
Median (range) | −10.8 (−58.3 to 73.0) | −5.9 (−82.9 to 71.4) |
Missing, n (%) | 6 (9.2) | 5 (7.7) |