Estimating dose-response for time to remission with instrumental variable adjustment: the obscuring effects of drug titration in Genome Based Therapeutic Drugs for Depression Trial (GENDEP): clinical trial data

Table 1 Predicting relative dose using linear regression. Regression output for prediction of relative dose from treatment and baseline covariates. The association measure is the regression coefficient (SE), with 95% CIs

Relative dose	Coefficient (SE)	95% CI	p value
MADRS	0.003 (0.002)	− 0.001 to 0.006	0.117
Prior duration of depression (weeks)	0.000 (0.001)	− 0.001 to 0.001	0.853
Sex (female)	0.046 (0.024)	0.000 to 0.093	0.052
Age of depression onset (years)	0.001 (0.001)	−0.002 to 0.004	0.399
BMI (kg/m²)	0.003 (0.002)	−0.001 to 0.008	0.149
Treatment (nortriptyline)	−0.131 (0.023)	−0.175 to − 0.086	< 0.001
Age (years)	− 0.002 (0.001)	− 0.005 to 0.000	0.060

BMI body mass index, CI confidence interval, MADRS Montgomery-Åsberg Depression Rating Scale, SE standard error

ISSN: 1745-6215