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Table 1 Inclusion and exclusion criteria

From: Pharmacological conditioning in the treatment of recent-onset rheumatoid arthritis: a randomized controlled trial study protocol

Inclusion criteria
1 Adult (minimum age of 18 years)
2 Recent-onset RA
3 Fluent in Dutch
4 Able to give informed consent
5. Clinical remission at month 5 after completing the protocolized pharmacological treatment
Exclusion criteria
1 Previous therapy with MTX
2 DMARD therapy in the last 6 months or for a period of 3 months or longer, with the exception of anti-malarial drugs
3 Pregnancy or wish to become pregnant during the study, or childbearing potential without adequate contraception
4 Concomitant treatment with another experimental drug
5 Bone marrow hypoplasia
6 Elevated hepatic enzyme levels (ASAT, ALAT > 3 times normal value)
7 Serum creatinine levels > 150 umol/l or estimated creatinine clearance of < 75%
8 Uncontrolled diabetes mellitus (according to the clinician)
9 Uncontrolled hypertension (according to the clinician)
10 Alcohol or drug abuse
11 History of infected joint prosthesis within the previous 3 months
12 Serious infections, such as hepatitis, pneumonia, and pyelonephritis in the previous 3 months
13 Chronic infectious disease, such as chronic renal infection or chronic chest infection with bronchiectasis or sinusitis
14 History of opportunistic infections, such as herpes zoster, within previous 2 months
  1. MTX methotrexate, DMARD disease-modifying antirheumatic drug, ASAT aspartate transaminase, ALAT alanine transaminase, umol micromole, NYHA New York Heart Association