| Measures | Pre | Mid | Post | f/u |
---|---|---|---|---|---|
Descriptive and Clinical Variables | |||||
 Demographic characteristics | Age, sex,a gender,a race, ethnicity, relationship status, education (years), residence (country/state/zip code), employment status, all assessed by self-report | X |  |  |  |
 Clinical variables | MS duration and diagnosis dateb MS severity: Expanded Disability Status Scale-self-report [18] MS course: NINDS CDE self-report questions on course [19] | X |  |  |  |
 Pain characteristics | Location of pain sites PainDETECT: pain type, including neuropathic pain [20] | X |  |  |  |
 Medications and treatments | List of all pain medications, disease modifying therapies, & non-pharmacologic pain treatments | X | X | X | X |
Primary Outcome | |||||
 Pain intensity | The 0–10 numeric rating scale of average pain intensity in past week [21] | X | X | X | X |
Secondary Outcomes | |||||
 Other pain intensity outcomes | Percentage with a meaningful improvement in average pain intensity (≥ 30% reduction from pre-treatment) Least, worst, and present pain assessed with 0–10 numeric rating scale | X | X | X | X |
 Pain interference | Brief Pain Inventory–Interference scale (modified version for MS) [21] | X | X | X | X |
 Physical function | PROMIS-29: 4 item version [22] | X | X | X | X |
 Depressive symptoms | Patient Health Questionnaire – 9 [23] | X | X | X | X |
 Fatigue severity | Modified Fatigue Impact Scale [24] | X | X | X | X |
 Sleep disturbance | PROMIS Sleep Disturbance scale [25] | X | X | X | X |
 Pain self-efficacy | UW CORR Pain Self-Efficacy Scale [26] | X | X | X | X |
 Treatment satisfaction | Patient Global Impression of Change [27] Patient Global Assessment of Treatment Satisfaction [27] |  |  | X | X |
 Global quality of life | Global Quality of Life Scale [28] | X | X | X | X |
Primary Moderators | |||||
 Pain catastrophizing | Pain Catastrophizing Scale [29] | X | X | X | X |
 Mindfulness | Five Facet Mindfulness Questionnaire [30] | X | X | X | X |
 Behavioral activation | Behavioral Activation for Depression Scale [31] | X | X | X | X |
Exploratory Moderators | |||||
 Pre-treatment pain intensity | The 0–10 numeric rating of average pain intensity [21] | X |  |  |  |
 Positive affect | Positive Affect scale of the Positive and Negative Affect Scale [32] | X | X | X | X |
 Pain acceptance | Chronic Pain Acceptance Questionnaire [33] | X | X | X | X |
 Pain beliefs | Survey of Pain Attitudes: 2-item versions of harm and control subscales [34] | X | X | X | X |
 Pain resilience | Pain Resilience Scale [35] | X | X | X | X |
 Tx outcome expectancy | 5-point Likert scale | X |  |  |  |
 Cognitive functioning | Brief Test of Adult Cognition by Telephone [36] | X |  |  |  |
 Age, sex, race/ethnicity | Demographic variables | X |  |  |  |
Process and Treatment-related Variables | |||||
 Therapeutic alliance | Working Alliance Inventory [37] |  | X | X |  |
 Group climate | Group Climate Questionnaire-Engage scale [38] |  | X | X |  |
 Treatment dose | Number, frequency, and duration of sessions attended |  | X | X |  |