Detailed statistical analysis plan for the SafeBoosC III trial: a multinational randomised clinical trial assessing treatment guided by cerebral oxygenation monitoring versus treatment as usual in extremely preterm infants

Table 3 Simulation study to assess power and coverage probabilities of confidence intervals of primary outcome

ICC	Proportion of twins	Power of naive analysis	Power of GEE analysis	Coverage probability of naive analysis	Coverage probability of GEE analysis
0	0.1	0.91	0.91	0.95	0.95
0	0.2	0.91	0.91	0.95	0.95
0	0.3	0.90	0.90	0.95	0.95
0	0.4	0.90	0.90	0.95	0.95
0.01	0.1	0.91	0.91	0.95	0.95
0.01	0.2	0.90	0.90	0.95	0.95
0.01	0.3	0.90	0.90	0.95	0.95
0.01	0.4	0.91	0.90	0.95	0.95
0.03	0.1	0.90	0.90	0.95	0.95
0.03	0.2	0.91	0.91	0.95	0.95
0.03	0.3	0.90	0.90	0.95	0.95
0.03	0.4	0.90	0.90	0.95	0.95
0.13	0.1	0.90	0.90	0.95	0.95
0.13	0.2	0.90	0.89	0.94	0.95
0.13	0.3	0.90	0.89	0.94	0.95
0.13	0.4	0.90	0.88	0.94	0.95
0.2	0.1	0.90	0.90	0.95	0.95
0.2	0.2	0.90	0.89	0.94	0.95
0.2	0.3	0.90	0.88	0.94	0.95
0.2	0.4	0.89	0.87	0.94	0.95

ISSN: 1745-6215