Baseline | Treatment phase | Follow-up phase | ||
---|---|---|---|---|
−1 day | 0 day | 2 weeks | 4 weeks | |
Patients | ||||
Informed consent | × | |||
Sign informed consent | × | |||
Medical history | × | |||
Physical examination | × | |||
Randomization | × | |||
Intervention FA group (n = 60) | Six sessions of FA | |||
Comparisons GA group (n = 60) | Six sessions of GA | |||
Outcomes | ||||
WOMAC | × | × | × | |
OMERACT–OARSI | × | × | × | |
MMP-3 | × | × | ||
IL-1β | × | × | ||
TNF-α | × | × | ||
SEE | × | × | × | |
Participant safety | ||||
Adverse events | × | × | × |