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Table 1 Fixed and constant parameter values for the interim analysis simulations

From: Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study

DescriptionConstant factorsFactors varied
Interim sample sizen = 50 
Minimum required sample sizen = 600 
Number of simulations1000 
Between-person SDσb = 10 mmHg 
Within person SD σe = 9, 10 mmHg
Overall mean SBP (mmHg)μ = 140 mmHg 
Single treatment-by-ethnic interaction (mmHg) δ = 3, 4 mmHg
Period effect (mmHg)πj = 0 mmHg, j 
Power to detect a single ethnic by treatment interaction at 5% significance level (%) 1 − β = 0.1,0.2