Table 1 Fixed and constant parameter values for the interim analysis simulations
From: Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study
Description | Constant factors | Factors varied |
|---|---|---|
Interim sample size | n = 50 | |
Minimum required sample size | n = 600 | |
Number of simulations | 1000 | |
Between-person SD | σb = 10 mmHg | |
Within person SD | σe = 9, 10 mmHg | |
Overall mean SBP (mmHg) | μ = 140 mmHg | |
Single treatment-by-ethnic interaction (mmHg) | δ = 3, 4 mmHg | |
Period effect (mmHg) | πj = 0 mmHg, ∀j | |
Power to detect a single ethnic by treatment interaction at 5% significance level (%) | 1 − β = 0.1,0.2 |