Neuropsychological management of multiple sclerosis: evaluation of a supervised and customized cognitive rehabilitation program for self-used at home (SEPIA): protocol for a randomized controlled trial

Table 1 Schedule of assessments

		Study period
		Screening	Baseline	Home-based intervention									Short-term follow-up	Long-term follow-up
Visits (weeks)		W-1	W0	W1	W2	W3	W4	W5	W6	W7	W8	W9	W10	W34
Informed consent		X
Eligibility screen		X
Randomization		X
Neuropsychological assessment 1	Cognitive complaint questionnaire	X
	BCcogSEP	X
	VAPS	X
	Multiple errands test	X
Neuropsychological assessment 2	MUSIQOL		X										X	X
	SEI		X										X	X
	MADRS		X										X	X
	HAMA		X										X	X
	BICAMS = SDMT, CVLT-II, BVMT-R		X										X	X
	MCQ-30		X										X	X
	EMIF-SEP		X										X	X
	PSQI		X										X	X
Active control group	At-home set-up			X
	Phone follow-up				X	X	X		X	X	X	X
	At-home follow-up							X
Experimental group with CR intervention	CR intervention				X	X	X	X	X	X	X	X
	At-home set-up			X
	Phone follow-up				X	X	X		X	X	X	X
	At-home follow-up							X

Abbreviations: BCcogSEP Batterie Courte d’évaluation des fonctions cognitives destinées aux patients souffrant de Sclérose En Plaques (French brief test battery evaluating cognitive functions in multiple sclerosis), BICAMS Brief International Cognitive Assessment for Multiple Sclerosis, BVMT-R Brief Visuospatial Memory Test – Revised, CR Cognitive rehabilitation, CVLT California Verbal Learning Test, EMIF-SEP Echelle Modifiée d’Impact de la Fatigue dans la Sclérose En Plaques (modified fatigue impact scale – multiple sclerosis), HAMA HAMilton Anxiety rating scale, MADRS Montgomery and Åsberg Depression Rating Scale, MCQ-30 MetaCognition Questionnaire-30, MUSIQOL MUltiple Sclerosis International Quality Of Life, PSQI Pittsburgh Sleep Quality Index, SDMT Symbol Digit Modalities Test, SEI Self Esteem Inventory, VAPS Virtual Action Planning Supermarket

ISSN: 1745-6215