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Fig. 2 | Trials

Fig. 2

From: An adaptive two-arm clinical trial using early endpoints to inform decision making: design for a study of sub-acromial spacers for repair of rotator cuff tendon tears

Fig. 2

Design characteristics for one early look. Estimated probabilities of stopping for futility and efficacy at the first look, expected sample size (ESS) and overall study power, for effect sizes in range 0 to 10 for a\(\alpha ^{*}_{L}=(0.24,0.975)\), b\(\alpha ^{*}_{L}=(0.48,0.975)\), c\(\alpha ^{*}_{L}=(0.72,0.975)\) and d\(\alpha ^{*}_{L}=(0.96,0.975)\). Here \(\alpha ^{*}_{U}(1)=0.001\), ρ=0.5; other settings are as in Table 1

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