The TREATT Trial (TRial to EvaluAte Tranexamic acid therapy in Thrombocytopenia): safety and efficacy of tranexamic acid in patients with haematological malignancies with severe thrombocytopenia: study protocol for a double-blind randomised controlled trial

Table 1 Dose adjustment for renal impairment

Serum creatinine		Dose IV	Dose PO	Oral suggested dose		Administration
μmol/L	mg/10 mL	Dose IV	Dose PO	Oral suggested dose		Administration
120 to 249	1.35 to 2.82	10 mg/kg BW	15 mg/kg BW	<50 kg	500 mg	Every 12 h
				50 to 83 kg	1 g
				84 to 116 kg	1.5 g
				>116 kg	2 g
250 to 500	2.82 to 5.65	10 mg/kg BW	15 mg/kg BW	<50 kg	500 mg	Every 24 h
				50 to 83 kg	1 g
				84 to 116 kg	1.5 g
				>116 kg	2 g
>500	>5.65	5 mg/kg BW	Omit dose			Every 24 h

ISSN: 1745-6215