Design, planning and implementation lessons learnt from a surgical multi-centre randomised controlled trial

Table 4 Agreement between self-completed measures of symptoms, incontinence, EQ-5D-5 L, and pain pre-randomisation and pre-treatment (baseline)

Measure	Mean change (95% agreement limits)		Difference in mean change	Ratio of variances
Measure	HAL	RBL	Difference in mean change	Ratio of variances
Haemorrhoid symptom score	0.0 (−3.0, 3.0)	0.1 (−3.0, 3.1)	−0.1 (p = 0.823)	0. 96 (p = 0.864)
EQ-5D-5L	−0.01 (− 0.13, 0.11)	−0.00 (− 0.12, 0.11)	−0.01 (p = 0.508)	1.11 (p = 0.691)
Vaizey Faecal incontinence score	−0.1 (−5.6, 5.3)	0.4 (−2.7, 3.5)	−0.5 (p = 0.231)	3.14 (p < 0.001)
VAS pain	0.2 (− 3.8, 4.2)	−0.0 (− 2.5, 2.4)	0.2 (p = 0.479)	2.63 (p < 0.001)

Reproduced with permission from Brown et al. 2016 [27]. HAL haemorrhoidal artery ligation, RBL rubber band ligation, EQ-5D-5L Euroqol - 5 dimensions - 5 levels questionnaire, VAS visual analogue scale

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