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Table 3 Secondary outcomes in NRT2Quit trial

From: Pragmatic randomised trial of a smartphone app (NRT2Quit) to improve effectiveness of nicotine replacement therapy in a quit attempt by improving medication adherence: results of a prematurely terminated study

 

Total (n = 41)

Intervention (n = 16)

Control (n = 25)

P valuea

Follow-up status, % (N)

    

 Successfully contacted at 8 weeks, % (N)

51.2 (21)

43.8 (7)

56.0 (14)

0.53

 Follow-up channel, % (N)

  Survey

29.3 (12)

31.3 (5)

28.0 (7)

0.50b

  Phone

22.0 (9)

12.5 (2)

28.0 (7)

 

  Not contacted

48.8 (20)

56.3 (9)

44.0 (11)

 

 Completed the survey on secondary outcomes, % (N)

29.3 (12)

31.3 (5)

28.0 (7)

1.00b

 Returned saliva samples when invited, % (n/N)

85.7 (6/7)

100.0 (4/4)

66.7 (2/3)

0.43

 App usage after initial registration1

  Logins, median (IQR)

1.0 (28.0)

2.5 (12.0)

0 (2.0)

0.01*

  Mean (SD)

5.1 (11.17)

10.2 (15.82)

1.8 (4.75)

0.05c

  Logins, % (N)

   0 logins

41.5 (7)

25.0 (4)

52.0 (13)

0.01d*

   1 login

12.2 (5)

6.3 (1)

16.0 (4)

 

   2–5 logins

31.7 (13)

3.7 (6)

28.0 (7)

 

   ≥6 logins

14.6 (6)

31.3 (5)

4.0 (1)

 

  Days logged in, median (IQR)

1.0 (10.0)

1.5 (5.0)

0.0 (1.0)

0.03*

  Mean (SD)

2.7 (5.98)

5.1 (8.35)

1.2 (3.18)

0.10c

  Days logged in, % (N)2

   0 days

41.5 (17)

25.0 (4)

52.0 (13)

0.02d*

   1 day

29.3 (12)

25.0 (4)

32.0 (8)

 

   2–7 days

19.5 (8)

31.3 (5)

12.0 (3)

 

   ≥8 days

9.8 (4)

18.8 (3)

4.0 (1)

 

Follow-up survey responses3

(n = 12)

(n = 5)

(n = 7)

 

 NRT use and other cessation behaviour,  % (N)

    

  Made a serious QA since registering

91.7 (11)

100.0 (5)

85.7 (6)

1.00

  Used additional cessation support

83.3 (10)

60.0 (3)

100.0 (7)

0.15

  Used NRT in past 8 weeks

83.3 (10)

80.0 (4)

85.7 (6)

1.00

  Used NRT on the day of follow-up

58.3 (7)

100.0 (5)

28.6 (2)

0.03*

  Used NRT for ≥5 weeks

66.7 (8)

100.0 (5)

42.9 (3)

0.08

  Used NRT every day in weeks when NRT used

58.3 (7)

40.0 (2)

71.4 (5)

0.56

App satisfaction

 App helpful for quitting (1–5)#, median (IQR)

3.0 (1.0)

3.0 (1.0)

2.0 (2.0)

0.07

 App helpful for quitting (1-5)# Mean (SD)

2.6 (.90)

3.2 (.45)

2.14 (.90)

0.04c*

 App helpful for NRT use (1–5)#, median (IQR)

3.0 (3.0)

4.0 (1.0)

2.0 (2.0)

0.02*

 App helpful for NRT use (1–5)#, Mean (SD)

2.7 (1.15)

3.6 (.55)

2.0 (1.00)

0.01*

 Recommend to others, % (N)

58.3 (7)

100.0 (5)

28.6 (2)

0.01*

  1. 1: App usage includes data from any new sessions after registration was completed and excludes the time of registration and initial app exploration following the registration; data on usage and logins may be an underestimation as app use during offline use would not synchronise with the study database if the participants did not access the app online on any future occasion; 2: not consecutive days; 3: data assessed via online survey among 12 respondents; #1 = not at all, 5 = extremely
  2. aFisher’s exact test for 2 × 2 and chi-squared for other categorical variables; bowing to small sample size, a considerable proportion of cells in chi-squared analyses had expected count of less than 5; cunequal variance; dlinear-by-linear association; * significant at p<0.05
  3. Abbreviations: IQR interquartile range, N number, NRT nicotine replacement therapy, QA quit attempt, SD standard deviation
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ISSN: 1745-6215