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Table 2 Perioperative protocol in each of the two treatment arms

From: Multimodal cardioprotective strategy in cardiac surgery (the ProCCard trial): Study protocol for a multicenter randomized controlled trial

 

Control group

Treated group

Maintenance of anesthesia

Propofol

Sevoflurane

RIPC

No

Three cycles of: 5 min inflation to 200 mmHg/5 min deflation

Intraoperative blood glucose (BG) management

BG control every 60 min. Intravenous insulin infusion if BG greater than 180 mg/ml

BG control every 30 min. Intravenous insulin infusion if BG greater than 140 mg/ml

pH level at the end of CPB, before aortic unclamping

pH ≥ 7.40

pH ≤ 7.30

Gentle reperfusion

No

Gradual recovery of the CPB flow (initial recovery of the flow at 20% of the theoretical flow, with an increase of 20% every 30 s, until complete restoration in 2 min)