High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial

Table 2 Detailed summary of data collection at study visits

Screening visit and informed consent
- Informational session about study requirements
- Obtain informed consent
- Verify inclusion criteria (i.e., BMI and blood pressure)
- Physical exam/review of medications
- Non-exercise physical activity via activPAL
- Exercise calendar and Barriers screening forms
- Complete metabolic panel, lipids, insulin, C-reactive protein, and blood chemistries
Baseline
- PWV, muscle biopsy, IVGTT, and NIRS
- SF-36 and FFQ
- Body weight, blood pressure, anthropometry, DEXA, and maximal exercise test
Randomization
- CON, MOD-INT, or HIGH-INT group
Mid-intervention (12 weeks)
- Waist circumference
- Body weight
- Maximal exercise test
Follow-up (24 weeks)
- Non-exercise physical activity via activPAL
- PWV, muscle biopsy, IVGTT, and NIRS
- SF-36 and FFQ
- Complete metabolic panel, lipids, insulin, C-reactive protein, and blood chemistries
- Body weight, blood pressure, anthropometry, DEXA, and maximal exercise test

Abbreviations: BMI body mass index, CON non-exercise control (group), DEXA dual-energy x-ray absorptiometry, FFQ food frequency questionnaire, HIGH-INT high-intensity exercise (group), IVGTT intravenous glucose tolerance test, MOD-INT moderate-intensity exercise (group), NIRS near-infrared spectroscopy, PWV pulse wave velocity, SF-36 short-form health survey

ISSN: 1745-6215