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Table 1 Categories of supportive evidence for diagnosis of chronic pancreatitis in this study

From: A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC)

Category

Description

1. Presence of pancreatic calcification(s)

Presence of one or more pancreatic parenchymal or ductal calcification(s) on cross-sectional abdominal imaging

2. Imaging supportive of chronic pancreatitis

Diagnosis requires the presence of a, b, or c:

a) EUS demonstrating lobular appearance of the pancreas and ≥ 3 minor criteria (Table 2)

b) EUS demonstrating ≥ 5 minor criteria

c) Presence of ≥ 3 abnormal pancreatic duct side branches on MRCP or ERCP

3. Indeterminate EUS with evidence of exocrine pancreatic insufficiency

Diagnosis requires the presence of a and b, c, d, or e:

a) Presence of 3–4 minor EUS criteria

b) Abnormal 72-h fecal fat collection (> 15 g fat per day)

c) Abnormal endoscopic pancreas function test (maximal duodenal bicarbonate concentration < 80 mEq/L)

d) Decreased serum trypsin (< 20 ng/mL)

e) Decreased fecal elastase level (< 200 mcg/g stool)

  1. EUS endoscopic ultrasound, MRCP magnetic resonance cholangiopancreatography, ERCP endoscopic retrograde cholangiopancreatography