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Table 1 Exploratory endpoints of this study

From: Comparative study of the inhibitory effect on bone erosion progression with denosumab treatment and conventional treatment in rheumatoid arthritis patients: study protocol for an open-label randomized controlled trial by HR-pQCT

1) HR-pOCT measurements
(1) Measurements in the second and third metacarpal bones and in the wrist joint • Changes from baseline in periarticular BMD • Changes from baseline in periarticular bone micro-architecture • Changes from baseline in the width of joint space • Changes from baseline in BMD at the rim of erosive lesions (2) Measurements in the tibial bone • Changes from baseline in BMD • Changes from baseline in bone micro-architecture
2) Magnetic resonance imaging measurements
• Changes from baseline in the extent of osteitis • Changes from baseline in the extent of bone erosion • Changes from baseline in synovitis score
3) Musculoskeletal ultrasound measurements
• Changes from baseline in synovitis score • Changes from baseline in the extent of bone erosion
4) X-ray measurements
• Changes from baseline in bone erosion score • Changes from baseline in joint space narrowing score • Changes from baseline in the modified total Sharp score
5) DXA measurements
• Changes from baseline in lumbar spine BMD • Changes from baseline in femoral BMD
6) Changes from baseline in bone/cartilage turnover markers
7) Changes from baseline in other biomarkers
8) Changes from baseline in DAS28
  1. Abbreviations: BMD bone mineral density, DAS28 disease activity score in 28 joints, DXA dual-energy x-ray absorptiometry, HR-pQCT high-resolution peripheral quantitative computed tomography.