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Table 3 Laboratory exceptions to the CTCAE list (version 4.0, guidelines)

From: Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia

ParameterGrade 2Grade 3Grade 4
Hemoglobin (Hb) (gm/dL)5.0–6.04.0–4.9< 4.0
Total WBC (×  109/L)1.0–1.9990.5–0.999< 0.5
ANC (× 109/L)0.5–0.9990.2–0.499< 0.2
Platelets (×  109/L)50–7920–49< 20
Total bilirubin (mg/dL)5.0–10.010.1–20.0> 20.0
AST (IU/L)150–300301–1000> 1000
ALT (IU/L)150–300301–1000> 1000
Creatinine (mg/dL)2× baseline serum creatinine and value ≥ 1.01.6–2.0> 2.0
ARC (×  109/L) and Hb < 7.0 gm/dL50–8010–49< 10
  1. WBC white blood cells, ANC absolute neutrophil count, AST aspartate aminotransferase, ALT alanine aminotransferase, ARC absolute reticulocyte count