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Table 3 Laboratory exceptions to the CTCAE list (version 4.0, guidelines)

From: Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia

Parameter

Grade 2

Grade 3

Grade 4

Hemoglobin (Hb) (gm/dL)

5.0–6.0

4.0–4.9

< 4.0

Total WBC (×  109/L)

1.0–1.999

0.5–0.999

< 0.5

ANC (× 109/L)

0.5–0.999

0.2–0.499

< 0.2

Platelets (×  109/L)

50–79

20–49

< 20

Total bilirubin (mg/dL)

5.0–10.0

10.1–20.0

> 20.0

AST (IU/L)

150–300

301–1000

> 1000

ALT (IU/L)

150–300

301–1000

> 1000

Creatinine (mg/dL)

2× baseline serum creatinine and value ≥ 1.0

1.6–2.0

> 2.0

ARC (×  109/L) and Hb < 7.0 gm/dL

50–80

10–49

< 10

  1. WBC white blood cells, ANC absolute neutrophil count, AST aspartate aminotransferase, ALT alanine aminotransferase, ARC absolute reticulocyte count