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Table 2 Sickle cell disease symptoms and associated conditions (Common Terminology Criteria for Adverse Events (CTCAE) version 4.0)

From: Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia

Acute chest syndromeDecreased lung functionHypertensionRenal papillary necrosis
Adenotonsillar diseaseDelayed growth/pubertyHypocalcemiaReticulocytopenia
AlbuminuriaDepressionHyposthenuriaReticulocytosis
AmenorrheaDizzinessNephropathyRetinopathy
Anemia (severe)Electrolyte imbalanceOsteomyelitisRetinal hemorrhage
Aplastic crisisElevated urinary urobilinogenPain, backRhabdomyolysis
ArthralgiaElevated serum transaminasesPain, chestSeizure
Avascular necrosis of hip/shoulderElevated transcranial doppler (TCD) ultrasound velocitiesPain, jointSepticemia
BacteremiaFeverPain, long boneSilent organ infarction
Bone infarctionEmpyemaPain, severe abdominalSkin ulcer
Cardiac arrythmiaHand-foot syndrome/dactylitisPain, sternal or ribSplenic sequestration
CardiomegalyHeadachePriapismSplenomegaly
Cerebrovascular accidentHematuriaProteinuriaStroke
CholecystitisHemiplegiaPneumoniaTransient ischemic attack (TIA)
CholelithiasisHemolysisPulmonary embolismTransfusion, unanticipated
Cognitive dysfunctionHepatic sequestrationPulmonary hypertensionVaso-occlusive pain
ConstipationHepatomegalyPulmonary infiltrate on chest x-ray 
Cranial nerve palsyHospitalization > 24 hPyelonephritis 
DeathHyperbilirubinemiaRenal failure 
Decreased renal functionHypersplenismRenal insufficiency