Table 2 Sickle cell disease symptoms and associated conditions (Common Terminology Criteria for Adverse Events (CTCAE) version 4.0)

Acute chest syndrome

Decreased lung function

Hypertension

Renal papillary necrosis

Adenotonsillar disease

Delayed growth/puberty

Hypocalcemia

Reticulocytopenia

Albuminuria

Depression

Hyposthenuria

Reticulocytosis

Amenorrhea

Dizziness

Nephropathy

Retinopathy

Anemia (severe)

Electrolyte imbalance

Osteomyelitis

Retinal hemorrhage

Aplastic crisis

Elevated urinary urobilinogen

Pain, back

Rhabdomyolysis

Arthralgia

Elevated serum transaminases

Pain, chest

Seizure

Avascular necrosis of hip/shoulder

Elevated transcranial doppler (TCD) ultrasound velocities

Pain, joint

Septicemia

Bacteremia

Fever

Pain, long bone

Silent organ infarction

Bone infarction

Empyema

Pain, severe abdominal

Skin ulcer

Cardiac arrythmia

Hand-foot syndrome/dactylitis

Pain, sternal or rib

Splenic sequestration

Cardiomegaly

Headache

Priapism

Splenomegaly

Cerebrovascular accident

Hematuria

Proteinuria

Stroke

Cholecystitis

Hemiplegia

Pneumonia

Transient ischemic attack (TIA)

Cholelithiasis

Hemolysis

Pulmonary embolism

Transfusion, unanticipated

Cognitive dysfunction

Hepatic sequestration

Pulmonary hypertension

Vaso-occlusive pain

Constipation

Hepatomegaly

Pulmonary infiltrate on chest x-ray

Cranial nerve palsy

Hospitalization > 24 h

Pyelonephritis

Death

Hyperbilirubinemia

Renal failure

Decreased renal function

Hypersplenism

Renal insufficiency