Infection | Definition |
---|---|
Abscess | Opaque, fluid-filled/fluctuant collection on skin (with purulent discharge if drained) |
Bacteremia | Children with a positive blood culture with a true pathogen (e.g., S. aureus, S. pneumoniae, Salmonella, other Gram-negative infections) |
Cellulitis | Area of reddened, warm skin in a child with a history of fever or measured axillary temperature of ≥ 37.5 °C |
Diarrhea | More than three loose stools in a 24-h period |
Dysentery | Fever with bloody stools |
Malaria | Measured fever (axillary temperature ≥ 37.5 °C) or fever by history and Plasmodium species infection on blood smear |
Meningitis/encephalitis | Fever with 1) nuchal rigidity or altered mental status and 2) CSF with > 5 WBC or with positive CSF culture for meningitis-associated organisms (e.g., S. pneumoniae, N. meningiditis, H. influenzae) |
Osteomyelitis | Fever with bone pain, redness of skin over bone and x-ray findings consistent with osteomyelitis |
Pharyngitis/tonsillitis | Inflamed, erythematous pharynx and/or tonsils, with pharyngeal or tonsillar exudates |
Pneumonia/acute chest syndrome (ACS) | Clinical syndrome characterized by a new pulmonary infiltrate and at least three of the following: chest pain, temperature greater than 38.5C, tachypnea, wheezing, or cough Children who have three or more of the above symptoms/signs must get a chest x-ray* |
Sepsis | Meets modified criteria for SIRS/sepsis in International pediatric sepsis consensus guidelines (two or more of the following criteria, one of which must be abnormal temperature: T ≥ 38.5 °C, age-specific tachycardia, age-specific tachypnea, age-specific leukopenia) Modified to remove leukocytosis because, per NOHARM study data, > 80% of children with SCA at Mulago Hospital will have age-specific leukocytosis at baseline, which is an IPSC criterion for SIRS/sepsis. Since SIRS in a child with SCA is always suspected to be due to infection, we will use the term sepsis |
Sinusitis (acute) | Congestion, nasal discharge or cough for more than 10 days without improvement; or symptoms of congestion with purulent nasal discharge for more than 3 days |
Urinary tract infection | Symptoms (fever with urinary frequency, burning or new incontinence after prior toilet training) plus urinalysis positive for LE or nitrite OR clean catch urine culture with > 100,000 colonies of a single pathogen |