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Table 1 Composition and action of yinang formulation in Chinese herbal medicine

From: Yinang formulation versus placebo granules as a treatment for chronic kidney disease stages III–IV in patients with autosomal dominant polycystic kidney disease: study protocol for a double-blind placebo-controlled randomized clinical trial

Ingredient Granule dose Action (TCM) Pharmaceutical action
Rhizoma sparganii (sanleng) 10 g 1. Regulate qi
2. Relieve pain
3. Promote blood circulation
4. Alleviate stagnation
1. Inhibit platelet aggregation and thrombosis
Ranunculus ternatus Thunb
(maozhuacao)
30 g 1. Dissipate phlegm
2. Dispel stasis
3. Detoxify
4. Detumescence
1. Anti-inflammation
2. Anti-tumor
Spina gleditsiae (zaojiaoci) 6 g 1. Detoxify
2. Disperse swelling
1. Anti-tumor
Rhizoma drynariae (gusuibu) 10 g 1. Reinforce the kidneys
2. Strengthen bones
3. Relieve pain
1. Prevent osteoporosis
2. Anti-inflammatory
Astragalus (huangqi) 30 g 1. Tonify qi
2. Diuresis
1. Improve the immune function
2. Anti-oxidant
3. Increase resistance to radiation
4. Anti-tumor
Codonopsis pilosula (dangshen) 30 g 1. Invigorate the spleen
2. Replenish qi
1. Regulate the central nervous system
2. Enhance immune function
3. Regulate gastrointestinal motility
4. Cardiovascular protective effect
Angelica sinensis (danggui) 10 g 1. Enrich the blood
2. Invigorate the circulation of blood
1. Anti-atherosclerosis
2. Bacteriostasis
3. Anti-hypoxia
4. Regulation of immune function 5. Inhibit platelet aggregation
Paeoniae radix (chishao) 15 g 1. Activate blood circulation to dissipate blood stasis 1. Inhibition of platelet and erythrocyte aggregation
2. Anti-atherosclerosis
3. Anti-tumor
4. Protect the heart and liver
5. Anti-coagulation and anti-thrombosis
Radix paeoniae alba (baishao) 10 g 1. Nourish the blood
2. Reduce yin
3. Soothe the liver
4. Relieve pain
5. Stabilize yin and yang in the liver
1. Anti-inflammation
2. Pain relief
3. Liver protection
Duchesnea indica (shemei) 10 g 1. Clear away heat and toxic material
2. Activate blood circulation to dissipate blood stasis
1. Anti-oxidant
Hedyotis diffusa willd (baihuasheshecao) 15 g 1. Dissolve phlegm
2. Detoxification
3. Detumescence
1. Anti-inflammation
2. Anti-tumor
3. Regulation of immune function
Cowherb seed (wangbuliuxing) 15 g 1. Activate blood circulation to dredge collaterals
2. Detumescence
3. Relieve pain
1. Inhibit microcapillary proliferation
2. Inhibit migration and adhesion of endothelial cells
Semen brassicae (baijiezi) 15 g 1. Activate qi
2. Activate blood circulation
3. Dredge collaterals
4. Relieve pain
1. Anti-hepatic fibrosis
2. Regulation of TGF-β1/Smad, NF-κB, and AKT signaling pathways
3. Reduction of extracellular matrix deposition
Plantaginis seeds (cheqianzi) 15 g 1. Clear heat
2. Diuresis
3. Permeate dampness
4. Promote circulation
5. Clear eyesight
6. Expectorant
1. Eliminate oxygenic free radicals
2. Anti-oxidation in lipid metabolism
3. Anti-oxidation
Polygonum cuspidatum (huzhang) 10 g 1. Relieve coughing
2. Resolve phlegm
3. Dispel wind dampness
4. Remove fluid
5. Dissipate blood stasis
6. Relieve pain
1. Anti-bacterial and anti-viral
2. Protect the cardiovascular system
3. Anti-inflammation and analgesic
4. Liver protection
5. Enhance immunity
6. Anti-tumor
Centella asiatica (jixuecao) 30 g 1. Clear heat
2. Disperse dampness
3. Detoxify
4. Reduce swelling
1. Improve the microcirculation
2. Relieve pain
3. Anti-oxidant
4. Anti-bacterial
5. Anti-inflammation
6. Anti-fibrous tissue proliferation
Prepared rhubarb (dahuang) 10 g 1. Alleviate accumulation
2. Clear heat
3. Detoxify
4. Remove blood stasis
5. Dredge meridians
1. Promote defecation
2. Anti-bacterial
3. Protect the liver and gallbladder 4. Lower blood pressure
5. Lower blood lipid levels
  1. TCM traditional Chinese medicine