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Table 1 Identified theoretical domains pertaining to VTE-PRO trial participation and compliance

From: Development of the IRIS-AR strategy: an intervention to improve rates of accrual and retention for the VTE-PRO randomized controlled trial

Barrier/facilitator to VTE-PRO trial

TDF domain

TDF construct group

COM-B component and intervention function

IRIS component

B: Misunderstanding of study processes (i.e., coming to hospital for injections)

F: Understand and are comfortable with study processes

Knowledge

Knowledge of task environment

Psychological capability – environmental restructuring/modeling

Physical capability – education

Inform

B: Fear of inability to administer heparin injection

F: No fear of injection

Beliefs about capabilities

Perceived competence

Reflective motivation – training

Inform, support

B: No direct benefits to self by participating

B: Fear of complications

F: Participation will further science, help others and themselves

Beliefs about consequences

Beliefs

Anticipated regrets

Outcome expectancies

Reflective motivation – training

Inform

B: Forget to self-administer injection daily

F: Remember to self-administer injection daily

Memory, attention and decision processes

Attention control

Memory

Psychological capability – modeling; environmental restructuring

Remind

F: Family/friend concerns about trial participation are considered, yet ultimately patients make final decision regarding participation

F: Social networks facilitate motivation, support, reminders for needle injections, and assistance with injections

Social influences

Social pressure

Social support

Social opportunity – education; persuasion

Involve

B: Feelings of fear, anxiety or stress pertaining to upcoming surgery

Emotion

Fear

Anxiety

Stress

Depression

Automatic motivation – enablement

Inform, involve, support

  1. B barrier, COM-B capabilities, opportunities and behavior, F facilitator, IRIS Inform, Remind, Involve and Support, TDF theoretical domains framework, VTE-PRO Venous Thromboembolism Prophylaxis