Step | Algorithm 1 (FENO high) | Algorithm 2 (FENO not high) |
---|---|---|
1 | Short-acting beta-agonist (SABA) as required only | SABA as required only |
2 | Budesonide (or beclomethasone) 200 μg daily plus SABA | Budesonide (or beclomethasone 200 μg twice daily plus SABA |
3 | Budesonide (or beclomethasone) 400 μg OR fluticasone 200 μg daily plus SABA | Budesonide (or beclomethasone) 400 μg OR fluticasone 200 μg daily plus SABA |
4 | Budesonide (or beclomethasone) 800 μg OR fluticasone 500 μg daily plus SABA | Add long-acting beta-agonist (LABA) |
5 | Only for ≥ 12-year-olds: Budesonide (or beclomethasone 1600 μg daily or fluticasone 1000 μg daily plus SABA. Go to step 6 for < 12-year-olds | Add leukotriene receptor antagonist |
6 | Add LABA in fixed dose combination | Budesonide 800 μg or fluticasone 500 μg daily in fixed dose combination |
7 | Add leukotriene receptor antagonist | Only for ≥ 12-year-olds. Budesonide (or beclomethasone 1600 μg daily or fluticasone 1000 μg daily plus SABA. Go to step 8 for < 12-year-olds |
8 | Refer for specialist assessment | Refer for specialist assessment |