Prevention of Morbidity in Sickle Cell Disease (POMS2a)—overnight auto-adjusting continuous positive airway pressure compared with nocturnal oxygen therapy: a randomised crossover pilot study examining patient preference and safety in adults and children

Table 6 Difference in the number of pain days between interventions

Method	Baseline – washout	Washout –APAP	Washout – NOT	Baseline – APAP	Baseline – NOT	APAP – NOT
Multiple imputation	1.02 (−0.146, 2.18)	−0.249 (−1.12, 0.536)	−0.244 (−1.23, 0.738)	1.58 (0.509, 2.65)	1.71 (0.791, 2.62)	−0.00569 (−0.385, 0.373)
Best case	1.00 (0, 2.00)	0.00 (0.00, 1.00)	0 (−1.00, 0.00)	1.00 (0.00, 2.00)	1.00 (0.00, 2.00)	0.00 (−1.00, 0.00)
Worst case	0.00 (0.00, 2.00)	0.00 (−1.00, 1.00)	0.00 (−1.00, 2.00)	1.00 (−1.00, 2.00)	2.00 (−1.00, 2.00)	0.00 (−1.00, 1.00)

Values are shown as median (95% confidence interval)
APAP auto-adjusting continuous positive airway pressure, NOT nocturnal oxygen therapy

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