Table 5 Piperacillin/tazobactam (TZP) dosing instructions for standard care arm

Loading dose (LD)

Patients without TZP therapy within 24 h prior to randomisation: 4.5 g TZP in 30 min

Patients with TZP therapy within 24 h prior to randomisation: at the discretion of the physician (depending on when last dose of TZP was administered)

Dose adjustment

According to current renal function (GFR) as measured with Cockroft-Gault formula or type of renal replacement therapy:

• eGFR ≥20 ml/min or CRRT or SLED: 13.5 g/24 h

• eGFR < 20 ml/min or IHD: 9 g/24 h