Table 4 Piperacillin/tazobactam (TZP) dosing instructions for experimental therapy arm
Loading dose (LD) | Patients without TZP therapy within 24 h prior to randomisation: 4.5 g TZP in 30 min | |
Patients with TZP therapy within 24 h prior to randomisation: at the discretion of the physician (depending on when last dose of TZP was administered) | ||
Continuous infusion (onset after finishing LD to first dose adjustment) | eGFR ≥20 ml/min 13.5 g/24 h | |
eGFR < 20 ml/min 9 g/24 h | ||
Dose adjustment - Start: day 1 after randomisation (optional on day of randomisation) | MIC | Piperacillin target concentrationa (mg/L) |
 Unknown pathogen or pathogen with MIC ≤16 mg/L | 80 [64–96] | |
 Pathogen with MIC ≤8 mg/L | 40 [32–48] | |
 Pathogen with MIC ≤4 mg/L | 20 [16–24] | |