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Fig. 1 | Trials

Fig. 1

From: Optimal management of HIV- positive adults at risk for kidney disease in Nigeria (Renal Risk Reduction “R3” Trial): protocol and study design

Fig. 1

Flow diagram of study medication dosing. Endpoints are outlined in dotted boxes. Symptomatic hypotension will be defined as a reading lower than 90 mm Hg systolic or 60 mm Hg diastolic pressure, with associated symptoms (i.e. feeling of lightheadedness, weakness). All low blood pressure (BP) readings will be confirmed, orthostatic blood pressure will be obtained (when clinically indicated/appropriate), and all readings will be put in context of the individual’s normal blood pressure readings. Patients removed from the study due to failure to tolerate either the primary (lisinopril) or alternative (losartan) study drug will be unblinded to enable their physicians to best treat any conditions. Hyperkalemia will be graded using the established DAIDS toxicity grading scale (Version 2.1, July 2017); with grade 3 hyperkalemia = 6.0–6.5 mmol/L and grade 4 hyperkalemia = 6.5–7.0 mmol/L. ARB, angiotensin receptor blockers

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