|
Testing schedule
|
Task
|
Telephone screen
|
Face-to-face screen
|
Baseline(0 months)
|
Midpoint(3 months)
|
Endpoint(6 months)
|
Follow-up 4 weeks after endpoint(7 months)
|
|---|
|
Screening assessment
|
TICS-M
|
X
| | | | | |
|
General medical history
| |
X
| | | | |
|
MoCA
| |
X
| | | | |
|
GDS
| |
X
| | | | |
|
RAVLT
| |
X
| | | | |
|
CogState® battery
|
Identification taska
| | |
X
|
X
|
X
| |
|
One card learning testa
| | |
X
|
X
|
X
| |
|
Detection testb
| | |
X
|
X
|
X
| |
|
One back testb
| | |
X
|
X
|
X
| |
|
CogState® additional test
|
Groton Maze learning testb
| | |
X
|
X
|
X
| |
|
Mood and fatigue outcome measures
|
DASS-42b
| | |
X
|
X
|
X
| |
|
SHAIb
| | |
X
|
X
|
X
| |
|
FACIT-Fb
| | |
X
|
X
|
X
| |
|
Electrophysiological tasks
|
Word list immediate and delayed recall tasksc
| | |
X
| |
X
| |
|
Resting-state EEGc
| | |
X
| |
X
| |
|
Equiprobable Go/NoGoc
| | |
X
| |
X
| |
|
Safety and compliance measures
|
FBC, E/LFT (bloods)b
| | |
X
| |
X
| |
|
Adverse effectsb
| | | |
X
|
X
|
X
|
|
Compliance and blinding
| | | |
X
|
X
|
X
|
- aCo-primary outcome measures
- bSecondary outcome measures
- cEEG tasks will be completed by a subset of participants
- DASS-42 Depression, Anxiety, Stress Scale, EEG electroencephalography, E/LFT electrolyte and liver function test, FACIT-F Functional Assessment of Chronic Illness Therapy Fatigue Scale, FBC full blood count, GDS Geriatric Depression Scale, MoCA Montreal Cognitive Assessment, RAVLT Rey Auditory Verbal Learning Test, SHAI Short Health Anxiety Inventory, TICS-M modified telephone interview for cognitive status
