Eligibility | Exclusion criteria |
---|---|
• Men or women 20–65 years of age | • Previous treatment with nifurtimox or benznidazole |
• Positive serology for T. cruzi (at least two different techniques applied to the same blood sample) in the last 10 years | • Lack of compliance/tolerance to a 10-day run-in period |
• No clinical suspicion, or active risk factors for, chronic cardiomyopathy | • Abnormal values in blood cell counts or laboratory tests for hepatic and renal function |
• Negligible risk of vector T. cruzi re-infection | • Any medical/social condition hindering free participation |
• Capable of complying with the planned study visits | • Current or planned pregnancy, or not using secure birth methods for women of childbearing age |