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Table 3 Randomised trials within the CONTRAST consortium

From: Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): study protocol for a randomised controlled trial

Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): pre-hospital augmentation of collateral blood flow and blood pressure reduction (ISRCTN99503308)

Multicentre Randomised CLinical trial of Endovascular treatment for Acute ischaemic stroke in the Netherlands. The effect of concomitant MEDication: heparin, antiplatelet agents, both or neither (MR CLEAN-MED): antithrombotics to prevent microvascular occlusion after EVT (ISRCTN76741621)

Intravenous treatment followed by intra-arterial treatment versus direct intra-arterial treatment for acute ischaemic stroke caused by a proximal intracranial occlusion (MR CLEAN-NO IV): immediate EVT without preceding thrombolysis (ISRCTN80619088)

Multicentre Randomised Clinical Trial of Endovascular Stroke treatment in The Netherlands for Late arrivals: (MR CLEAN-LATE): EVT in the 6 to 24 h time window (ISRCTN19922220)

The Dutch ICH Surgery Trial pilot study (DIST pilot study): minimally invasive endoscopy-guided surgery for spontaneous intracerebral haemorrhage (NCT03608423)

  1. CONTRAST Collaboration for New Treatments of Acute Stroke, EVT endovascular treatment, ICH intracerebral haemorrhage