Table 2 Patient diary, general symptoms
| Grade 1: mild | Grade 2: moderate | Grade 3: severe | Grade 4: extreme | |
|---|---|---|---|---|
| Chills/rigors | Mild hot/cold flushes requiring blanket or occasional painkillers/antipyretics | Limiting daily activity > 6 h or need regular painkillers/antipyretics | Uncontrollable shaking, treatment from doctor needed | Hospitalization |
| Malaise/tiredness | Normal activity reduced – not bad enough to go to bed | Fatigue such that 0.5 days in bed for 1 or 2 days | Fatigue such that is in bed all day or 0.5 day for more than 2 days | Hospitalization |
| General muscle aches | No limitation of activity | Muscle tenderness, limited activity, e.g., difficulty climbing stairs | Severe limitation, e.g., cannot climb stairs | Hospitalization |
| Headache | No treatment or responds to usual treatment like paracetamol | Occasional treatment like paracetamol needed | Strong pain killers needed (with prescription) | Hospitalization |
| Nausea | Intake maintained | Intake reduced at most 3 days | Minimal intake 3 days or more | Hospitalization |
| Vomiting | Less than 4 × a day or lasting less than 1 week | At least 4 x a day or lasting 1 week or more | Unable to keep any food of fluids down | Hospitalization |