Table 1 Characteristics of STAMPEDE and FOCUS4
Trial characteristic | STAMPEDE | FOCUS4 |
|---|---|---|
Disease setting | Prostate cancer | Colorectal cancer |
Registration numbers | ||
 ISRCTN | ISRCTN78818544 | ISRCTN90061546 |
 EudraCT | 2004-000193-31 | 2012-005111-12 |
 ClinicalTrials.gov | NCT00268476 | Not available |
Date first patient randomised | October 2005 | January 2014 |
Multiple comparisons | Yes | Yes |
Multi-stage elements | Yes | Yes |
Comparisons for specific sub-groups (stratified elements) | Yes (defined by metastases; diabetic status) Pending (defined by biomarker) | Yes (defined by biomarker) |
Shared control arm | Yes | No |
Initial comparisons open | 5 | 2 |
New research comparisons added | 5 | 3 |
Research comparisons closed for lack of benefit | 2 | 1 |
Research comparisons reached recruitment target | 6 | Pending |
Eligibility criteria revised | Yes | Yes |
Stratification criteria revised | Yes | Yes |
New biomarker classifications added | Pending | Yes |
Updates of standard of care | 3 | 0 |
Patients recruited so far | > 10,000 | > 900 |
Data collected on paper CRFs | Yes | Limiteda |
Data entered from source notes straight into database | No | Yes |
Data entry | Staff at CTU | Staff at sites (excepta) |
Randomisation | Sites call CTU to randomise | Sites call CTU to randomise |