Table 2 Comparison by treatment group at each assessment period

 1st Week

5.80 [5.18, 6.42]

5.50 [5.01, 5.99]

6.05 [5.51, 6.59]

0.176^c

 7th Week

2.53 [1.78, 3.28]

3.55 [2.73, 4.37]

4.30 [3.25, 5.35]

0.016^b

 Difference

− 3.28 [− 4.08, − 2.47]

−1.95 [− 2.82, − 1.08]

−1.75 [− 2.70, − 0.80]

0.021^c

 P value

< 0.001^e

< 0.001^f

0.005^f

 1st Week

3.60 [2.23, 4.97]

1.85 [0.70, 3.00]

4.40 [2.98, 5.82]

0.018^c

 7th Week

1.15 [0.40, 1.90]

1.15 [0.45, 1.85]

2.55 [1.53, 3.57]

0.053^c

 Difference

− 2.45 [− 3.53, − 1.37]

−0.70 [− 1.73, 0.33]

−1.85 [− 3.10, − 0.60]

0.096^c

P value

< 0.001^f

0.140^f

0.015^f

 1st Week

25.17 [22.12, 28.22]

26.06 [22.42, 29.70]

28.47 [24.55, 28.57]

0.388^b

 7th Week

12.88 [9.00, 16.75]

15.71 [11.39, 20.04]

19.20 [13.75, 24.65]

0.135^b

 Difference

− 12.29 [− 16.86, − 7.72]

−10.34 [− 14.63, − 6.06]

−9.27 [− 14.28, − 4.26]

0.933^c

 P value

< 0.001^e

< 0.001^f

0.001^e

 1st Week

–

–

–

–

 7th Week

6.00 [5.60, 6.39]

5.06 [4.62, 5.49]

5.53 [5.06, 5.99]

0.011^c

 1st Week

0.70 [0.62, 0.79]

0.74 [0.71, 0.76]

0.63 [0.53, 0.73]

0.078^c

 7th Week

0.88 [0.79, 0.92]

0.81 [0.75, 0.87]

0.77 [0.70, 0.84]

0.180^c

 Difference

0.16 [0.06, 0.25]

0.07 [0.01, 0.14]

0.14 [0.03, 0.25]

0.421^b

 P value

0.002^f

0.033^f

0.019^f

 1st Week

0.88 [0.82, 0.93]

0.88 [0.82, 0.94]

0.91 [0.87, 0.95]

0.750^c

 7th Week

0.95 [0.92, 0.98]

0.93 [0.89, 0.97]

0.91 [0.86, 0.95]

0.233^c

 Difference

0.07 [0.02, 0.17]

0.05 [−0.01, 0.11]

0.00 [− 0.04, 0.03]

0.037^c

 P value

0.011^f

0.054^f

0.857^f

 1st Week

89.00 [84.60, 93.40]

89.30 [85.71, 92.89]

81.65 [73.10, 90.20]

0.261^c

 7th Week

94.00 [90.01, 97.99]

88.50 [83.35, 93.66]

88.00 [79.60, 96.40]

0.253^c

 Difference

5.00 [−0.68, 10.68]

−0.80 [− 3.77, 2.17]

6.35 [− 0.46, 13.16]

0.026^c

 P value

0.063^f

0.579^e

0.049^f