Exclusion criterion | |
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1. Patients receiving beta-blockers or calcium antagonists for the purpose of treatment of CHHF | |
2. Patients with one or more ulcers or gangrene of the finger | |
3. Those who have been diagnosed with hypothyroidism or prescribed thyroid medications | |
4. Those who have been diagnosed with autoimmune diseases | |
5. Those who have been diagnosed with carpal tunnel syndrome or have positive results on Phalen’s and Tinel’s tests | |
6. Those who have been diagnosed with cervical disc herniation | |
7. Those who have been diagnosed with diabetes mellitus | |
8. Those receiving medicines that can affect the symptoms of CHHF, such as anticoagulants | |
9. Those who present with CHHF due to postpartum or menopausal syndrome | |
10. Those who present with a moderate level of liver dysfunction (AST and ALT levels of > 100 IU/L) or kidney dysfunction (creatinine level of > 2.0 mg/dl) | |
11. Those who have behavior disorder, depression, anxiety, neurosis, or any other severe mental disorder | |
12. Adult nonpregnant women with a hemoglobin level of < 7 g/dl and WBC count of > 11 cells × 109 L | |
13. Those whose mean SBP is ≥ 180 mmHg or DBP is ≥ 100 mmHg when measured twice | |
14. Patients with an arrhythmia as determined by an electrocardiogram and requiring treatment, or with heart disease such as ischemic heart disease | |
15. Alcohol or drug abusers | |
16. Women who are pregnant (urine hCG positive), lactating women, and fertile women who have a pregnancy plan or do not consent to the proper method of contraception | |
17. Those who have been diagnosed with a malignant tumor | |
18. Those who are participating in other clinical trials | |
19. Those who refuse to participate in clinical trials or provide written informed consent | |
20. Those who cannot understand or speak Korean | |
21. Those who are judged to be inappropriate for clinical trials by the researchers |