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Table 4 Alpha spend for interim analyses

From: The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

Interim analysis

Alpha spend

N = 200

0.0002

N = 300

< 0.0001

N = 400

0.0003

N = 500

0.010

N = 1000

0.0026

N = 1500

0.0033

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Trials

ISSN: 1745-6215