Physical Activity In Renal Disease (PAIRED) and the effect on hypertension: study protocol for a randomized controlled trial

Table 1 Overview of trial outcomes by study visit

Outcome measure	Method	Baseline	Study visit 1 8 weeks	Study visit 3 24 weeks
Blood pressure	24-h ABPM Clinic BP with an automated oscillometric device	X	X	X
Anti-hypertensive dosing	Tabulated using the Defined Daily Dose (DDD)	X	X	X
Aortic stiffness	Pulse-wave velocity	X	X	X
Medication adherence	Questionnaire	X	X	X
Markers of cardiovascular risk Lipids, HgA₁C, C-reactive protein Albuminuria, sodium intake Body composition	Blood samples Spot urine sample Bioimpedance spectroscopy, BMI	X	X	X
Cardiorespiratory fitness	Cardiopulmonary exercise testing Six-min Walk Test	X	X	X
Physical activity	7-day accelerometry IPAQ-SF	X	X	X
Quality of life	KDQoL-36 EQ-5D	X	X	X
Self-efficacy	Self-efficacy for Exercise scale	X	X	X
Adherence	7-day accelerometry Participant logbook		X	X
Adverse events	Self report and health record verification	X	X	X

Baseline data is collected prior to randomization. Adverse events are also collected by phone follow-up every 2 weeks for the first 8 weeks and every 4 weeks from weeks 8 to 24
Abbreviations: ABPM ambulatory blood pressure monitoring, BMI Body Mass Index, BP blood pressure, EQ-5D EuroQol Health Questionnaire, HgA₁C hemoglobin A₁C, IPAQ-SF International Physical Activity Questionnaire Short Form, KDQoL-36 The Kidney Disease and Quality of Life Instrument,

ISSN: 1745-6215