How context can impact clinical trials: a multi-country qualitative case study comparison of diagnostic biomarker test interventions

Table 1 Clinical trial characteristics

	Case study
	Chiang Rai (Thailand)	Yangon (Myanmar)	Hanoi (Vietnam)
Study population	Febrile patients	Febrile patients	Patients with acute respiratory infections
Trial sample	1182 Participants (600 adults, 582 children)	1228 Participants (609 adults, 619 children)	2036 Participants (1008 adults, 1028 children)
CRP POCT users^a	Nurses and public health technical officers^b	Medical doctors	Medical doctors
Location	Peri-urban Chiang Rai district	Hlaing Tha Yar and Shwe Pyi Thar sub-urbs	Rural and urban Hanoi
Study sites	6 Public primary healthcare centres	3 NGO clinics and 1 public hospital	9 Public primary healthcare centres (urban) and 1 public district hospital (rural)

Source: Authors
CRP POCT C-reactive protein point-of-care test, NGO non-governmental organisation
^a“Users” refers here to the healthcare workers who interpreted the test results. The trials involved dedicated study staff to operate the CRP POCT, which would not necessarily be the case in routine settings
^bFor simplicity, we will only refer to “nurses” when considering healthcare workers in Chiang Rai

ISSN: 1745-6215