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Table 2 Summary of outcome measures for OxCaMS

From: The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study

Primary outcome

 The effect of L-type voltage-gated calcium channel (LTCC) antagonism on cognitive instability

Secondary outcomes

 The effect of LTCC antagonism on mood instability

 The effect of LTCC antagonism on physical activity and sleep

 The effect of LTCC antagonism on neural dynamics, at rest and during task performance

 The effect of LTCC antagonism on heart rate variability

 The effect of LTCC antagonism on calcium channel expression and calcium signalling

 The effect of rs1006737 genotype and its interaction with LTCC antagonism on the above measures

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Trials

ISSN: 1745-6215