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Table 1 Summary statistics on outcome reporting discrepancies

From: COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time

  Journal name Annals BMJ JAMA Lancet NEJM Total
Basic information Number of trials included 5 3 13 24 22 67
Journal listed as “endorsing CONSORT” Yes Yes Yes Yes Yes All
Protocol availability Pre-trial protocol with pre-specified outcomes available? 0 0 7 3 19 29
Percentage of pre-trial protocols available 0.0% 0.0% 53.9% 12.5% 86.4% 43.3%
Missing primary outcomes Trials with any unreported primary outcomes 4 2 2 4 1 13
Percentage of trials with any unreported primary outcomes 80.0% 66.7% 15.4% 16.7% 5.0% 19.4%
Primary outcomes Total number of primary outcomes pre-specified 9 4 22 34 28 97
Number of primary outcomes correctly reported as primary outcomes 4 1 18 24 27 74
Percentage of primary outcomes correctly reported 44.4% 25.0% 81.8% 70.6% 96.4% 76.3%
Number of primary outcomes reported anywhere 7 1 18 24 28 78
Percentage of primary outcomes reported anywhere 77.8% 25.0% 81.8% 70.6% 100.0% 80.4%
Secondary outcomes Total number of secondary outcomes pre-specified 49 36 111 218 404 818
Number of secondary outcomes correctly reported as secondary outcomes 15 26 78 141 190 450
Percentage of secondary outcomes correctly reported 30.6% 72.2% 70.3% 64.7% 47.0% 55.0%
Number of secondary outcomes reported anywhere 15 26 78 142 190 451
Percentage of secondary outcomes reported anywhere 30.6% 72.2% 70.2% 65.1% 47.0% 55.1%
Novel outcomes Number of novel outcomes reported without declaration 32 25 53 192 63 365
Mean number of novel outcomes reported without declaration, per trial 6.4 8.3 4.1 8 2.9 5.4 (95% CI 1.2–10.6)
Percentage of novel outcomes declared as novel 5.9% 0% 39.1% 9.4% 3.1% 13.7% (95% CI 0.0–42.5%)
  1. Abbreviations: BMJ British Medical Journal, CI confidence interval, CONSORT Consolidated Standards of Reporting Trials, JAMA Journal of the American Medical Association, NEJM New England Journal of Medicine