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Table 2 Schedule of assessments at baseline and post intervention

From: Mechanical suppression of osteolytic bone metastases in advanced breast cancer patients: a randomised controlled study protocol evaluating safety, feasibility and preliminary efficacy of exercise as a targeted medicine

Measures Baseline Post intervention
Tumour morphology (off-site)
 - MRI: T1-axial X X
Tumour biomarkers
 - Blood: HIF-1α, TGF-β X X
Anthropometry
 - Height (cm) X  
 - Weight (kg) X X
 - Waist circumference (cm) X X
 - Hip circumference (cm) X X
 - Femoral length (mm) X  
 - Tibial length (mm) X  
 - Body mass index (kg/m2) X X
 - Waist-to-hip ratio X X
Body composition
 - DXA: whole-body, spinal, hip X X
 - pQCT: femoral, tibial X X
Physical assessments
 - NeuroCom Balance Test X X
 - 1RM Strength Test (Leg Extension) X X
 - 400 m Walk Test X X
 - Timed Up and Go Test X X
Other biomarkers (off-site)
 - Blood: P1NP, ALP, CRP, fasting glucose and lipids X X
 - Urine: NTx X X
Questionnaires
 - Demographic and health history X  
 - Concomitant medications X X
 - Health-related quality of Life (SF-36) X X
 - Cancer-specific quality of life (EORTC: QLQ30, BR23) X X
 - Bone Pain (FACIT-BP) X X
 - Brief Symptom Index (BSI-18) X X
 - Insomnia Severity Index (ISI) X X
 - Godin Leisure-time Exercise X X
Exercise programme
 - Clinic exercise record sheet (prescribed vs. actual) At each exercise session
 - Home exercise record sheet (prescribed vs. actual) At each exercise session
 - Pre-session bone pain, muscle soreness and fatigue (VAS) At each exercise session
 - Post-session rating of perceived exertion and tolerance (VAS) At each exercise session
  1. Abbreviations: HIF-1α hypoxia-inducible factor 1-alpha, TGF-β transformation growth-like factor beta, DXA dual-energy x-ray absorptiometry, pQCT peripheral quantitative computed tomography, P1NP amino-terminal propeptide of type 1 procollagen, NTx amino-terminal collagen type-1 telopeptide, ALP alkaline phosphatase, CRP C-reactive protein, SF-36 Short Form-36, EORTC European Organisation for Research and Treatment of Cancer, FACIT-BP Functional Assessment of Chronic Illness Therapy-Bone Pain, VAS visual analogue scale