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Table 1 Antibiotic regimens used in the four study arms

From: Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial

  Short-term arm Long-term arm
Mono-prophylaxis Cefazolin 2–3 ga preop
Cefazolin 2 g at wound closure/4 h after the preop dose
No post-op antibiotics
Cefazolin 2–3 ga preop
Cefazolin 2 g at wound closure/4 h after the preop dose
Cefazolin 2 g q8h × 5 doses
Combination prophylaxis Cefazolin as above
Vancomycin 1–1.5 gb preop
No post-op antibiotics
Cefazolin as above
Vancomycin 1–1.5 gb preop,
repeated q12h × 3 doses
  1. Doses of both cefazolin and vancomycin will be adjusted for patients with known renal impairment
  2. Preop preoperative, q8h every 8 h, q12h every 12 h
  3. aCefazolin 3 g if patient weight greater than 120 kg
  4. bVancomycin 1.5 g if patient weight greater than 85 kg