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Table 1 Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) eligibility criteria

From: Methods in the design and implementation of the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) clinical trial

Inclusion criteria:
 • ≥ 2 weeks of age, ≥ 42 weeks post-menstrual age, and < 18 years of age
 • Supported on mechanical ventilation for acute lung disease. Lung disease includes both airways and parenchymal disease
Exclusion criteria:
 • Cyanotic heart disease with unrepaired or palliated right to left intracardiac shunt
 • History of single ventricle at any stage of repair
 • Congenital diaphragmatic hernia or congenital/acquired diaphragm paralysis
 • Primary pulmonary hypertension
 • Critical airway (e.g., post laryngotracheal reconstruction) or anatomical obstruction of the lower airway (e.g., mediastinal mass)
 • Ventilator dependent (including non-invasive) on PICU admission (chronic assisted ventilation)
 • Neuromuscular respiratory failure
 • Spinal cord injury above the lumbar region
 • Pain managed by patient-controlled analgesia (PCA) or epidural catheter
 • Patient transferred from an outside ICU where sedatives had already been administered for more than 24 h
 • Family/medical team have decided not to provide full support (patient treatment considered futile)
 • Enrolled in any other critical care interventional clinical trial concurrently or within the last 30 days
 • Known allergy to any of the study medications
 • Pregnancy