Inclusion criteria | |
Patients will be eligible for inclusion in the study if all the following criteria are met: | |
1. The treating clinician believes that the patient requires continuous renal replacement therapy for acute kidney injury | |
2. The treating clinicians anticipate treating the patient with continuous renal replacement therapy for at least 72 h | |
3. Informed consent has been obtained | |
4. The patient fulfills one of the following clinical criteria for initiating continuous renal replacement therapy: | |
Urine output < 100 mL/6 h that has been unresponsive to fluid resuscitation measures | |
K+ > 6.5 mmol/L | |
pH < 7.2 | |
Urea > 25 mmol/L | |
Clinically significant organ edema in the setting of acute kidney injury | |
5. Patients who are over 5% of fluid overload or their total body water/height2 ≥ 13 L/m2 | |
Exclusion criteria | |
Patients will be excluded from the study if, in the opinion or knowledge of the responsible clinician any of the following criteria are present: | |
1. Patient age is < 18 years | |
2. Death is imminent (< 24 h) | |
3. There is a strong likelihood that the study treatment will not be continued in accordance with the study protocol. | |
4. The patient has been treated with continuous renal replacement therapy or other dialysis previously during the same hospital admission. | |
5. The patient has been on maintenance dialysis prior to the current hospitalization. | |
6. Any other major illness that, in the investigator’s judgment, will substantially increase the risk associated with the subject’s participation in this study. |