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Table 2 Data collected from participants over time (S: Screening)

From: Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial

Variables Measures (data types) Source of data collection S Month
  0 3 6 12 18
Cognitive outcomes
 Executive function EXAMINER (continuous) Computer-based and paper based test   x x x x x
 Episodic verbal memory RAVLT (continuous) Pencil-paper-based test x   x x x x
 Episodic visual memory BVMT-R (continuous) Pencil-paper-based test   x x x x x
 AD conversion-clinical Consensus diagnosis using 2011 criteria for probable AD (categorical) All data collected     x x x
 MCI reversion ADNI criteria (categorical) All data collected     x x x
MRI mechanistic outcomes
 Cortical thickness Structural MRI (continuous) Device measured x    x x x
 Functional connectivity in DMN: resting state fMRI (continuous) Device measured x    x x x
Aerobic fitness outcomes
 Aerobic fitness Symptom-limited peak cycle-ergometer test (continuous) Performance-based test x   x x x x
 Aerobic fitness 10-m ISWT (continuous) Performance-based test   x x x x x
Other variables
 Implementation consistency Consistency checklist (continuous) REDCap report Monthly
 Global cognition MoCA (continuous) Pencil-paper-based test x   x x x x
 Daily functioning and mood ADL-PI, WHODAS (all continuous) Self-report, paper form x   x x x x
 Depression GDS (continuous) Self-report, paper form x x x x x x
 Medical changes Medical diagnoses, falls, medications, and health service use (all categorical) Self-report, paper form Monthly
 Demographics Age, education (both continuous), gender, race (both discrete) Self-report, paper form x      
 Premorbid intellect WTAR (continuous) Pencil-paper-based test x      
 Non-study physical and mental activities Wearable activity monitor, PASE questionnaire, MLA monthly (continuous) Wrist device; pencil-paper-based questionnaire Monthly
 Adherence Percent (continuous) Paper form Monthly
  1. Tests administered during screening will be used as baseline data to avoid practice effects
  2. AD Alzheimer’s disease, ADL-PI Activities of Daily Living-Prevention Instrument, ADNI Alzheimer’s Disease Neuroimaging Initiative, BVMT-R Brief Visuospatial Memory Test-Revised, ISWT Incremental Shuttle Walk Test, MCI mild cognitive impairment, MLA mental leisure activity, MoCA Montreal Cognitive Assessment, MRI magnetic resonance imaging, PASE Physical Activity Scale for the Elderly, RAVLT Rey Auditory Verbal Learning Test, WHODAS World Health Organization Disability Assessment Schedule, WTAR Wechsler Test of Adult Reading