Skip to main content

Table 2 Data collected from participants over time (S: Screening)

From: Efficacy and mechanisms of combined aerobic exercise and cognitive training in mild cognitive impairment: study protocol of the ACT trial

Variables

Measures (data types)

Source of data collection

S

Month

 

0

3

6

12

18

Cognitive outcomes

 Executive function

EXAMINER (continuous)

Computer-based and paper based test

 

x

x

x

x

x

 Episodic verbal memory

RAVLT (continuous)

Pencil-paper-based test

x

 

x

x

x

x

 Episodic visual memory

BVMT-R (continuous)

Pencil-paper-based test

 

x

x

x

x

x

 AD conversion-clinical

Consensus diagnosis using 2011 criteria for probable AD (categorical)

All data collected

   

x

x

x

 MCI reversion

ADNI criteria (categorical)

All data collected

   

x

x

x

MRI mechanistic outcomes

 Cortical thickness

Structural MRI (continuous)

Device measured

x

  

x

x

x

 Functional connectivity in DMN: resting state

fMRI (continuous)

Device measured

x

  

x

x

x

Aerobic fitness outcomes

 Aerobic fitness

Symptom-limited peak cycle-ergometer test (continuous)

Performance-based test

x

 

x

x

x

x

 Aerobic fitness

10-m ISWT (continuous)

Performance-based test

 

x

x

x

x

x

Other variables

 Implementation consistency

Consistency checklist (continuous)

REDCap report

Monthly

 Global cognition

MoCA (continuous)

Pencil-paper-based test

x

 

x

x

x

x

 Daily functioning and mood

ADL-PI, WHODAS (all continuous)

Self-report, paper form

x

 

x

x

x

x

 Depression

GDS (continuous)

Self-report, paper form

x

x

x

x

x

x

 Medical changes

Medical diagnoses, falls, medications, and health service use (all categorical)

Self-report, paper form

Monthly

 Demographics

Age, education (both continuous), gender, race (both discrete)

Self-report, paper form

x

     

 Premorbid intellect

WTAR (continuous)

Pencil-paper-based test

x

     

 Non-study physical and mental activities

Wearable activity monitor, PASE questionnaire, MLA monthly (continuous)

Wrist device; pencil-paper-based questionnaire

Monthly

 Adherence

Percent (continuous)

Paper form

Monthly

  1. Tests administered during screening will be used as baseline data to avoid practice effects
  2. AD Alzheimer’s disease, ADL-PI Activities of Daily Living-Prevention Instrument, ADNI Alzheimer’s Disease Neuroimaging Initiative, BVMT-R Brief Visuospatial Memory Test-Revised, ISWT Incremental Shuttle Walk Test, MCI mild cognitive impairment, MLA mental leisure activity, MoCA Montreal Cognitive Assessment, MRI magnetic resonance imaging, PASE Physical Activity Scale for the Elderly, RAVLT Rey Auditory Verbal Learning Test, WHODAS World Health Organization Disability Assessment Schedule, WTAR Wechsler Test of Adult Reading