Functional brain activation changes associated with practice in delaying smoking among moderate to heavy smokers: study protocol and rationale of a randomized trial (COPE)

Table 1 Examples of cognitive control regimens for the practice group

	Delay to 1st cigarette calculation	Example for smoker who smokes 1st cigarette of the day 5 min after waking and 2nd cigarette of the day 60 min later	Example for smoker who smokes 1st cigarette of the day 30 min after waking and 2nd cigarette of the day 90 min later
Baseline week (days 1–7)	Usual time	5 min	30 min
Day 8	Usual time + 0.33 of usual time to 2nd cigarette	~ 25 min	~ 60 min
Day 9	Usual time + 0.5 of usual time to 2nd cigarette	~ 35 min	~ 75 min
Day 10	Usual time + 0.66 of usual time to 2nd cigarette	~ 45 min	~ 90 min
Day 11	Usual time + 1.00 of usual time to 2nd cigarette	~ 65 min	~ 120 min
Day 12	Usual time + 1.33 of usual time to 2nd cigarette	~ 85 min	~ 150 min
Day 13	Usual time + 1.5 of usual time to 2nd cigarette	~ 95 min	~ 165 min
Days 14–20	Usual time + 1.66 of usual time to 2nd cigarette	~ 105 min	~ 180 min
Day 21 (follow-up fMRI)	Usual time	5 min	30 min

ISSN: 1745-6215