Estimated coefficient (95% CI); p value | Sensitivity analysisD Estimated coefficient (95% CI); p value | |
---|---|---|
ICombinedER A n = 112 (R2 = 0.11, p = 0.11) | n = 163 | |
The respondent has been involved with more than 15 trials | 0.11 (−1.37, 1.42); 0.860 | 0.22 (− 1.25, 1.70); 0.746 |
The respondent has been involved with more than 15 trials that had a DSMB monitoring the trial | 0.69 (− 0.29, 1.67); 0.230 | 0.69 (− 0.46, 1.83); 0.224 |
The respondent has been involved with more than 15 trials that had some form of private industry sponsorship | −0.35 (− 1.42, 0.77); 0.501 | − 0.28 (− 1.19, 0.63); 0.547 |
Primary profession by training | ||
● Other (reference category) | ||
● Mathematician/statistician/biostatistician | 0.87 (−0.17, 2.06); 0.127 | 0.37 (−0.64, 1.38); 0.472 |
● Methodological scientist/research Methodologist | 1.03 (−0.47, 2.47); 0.159 | 0.86 (−0.48, 2.21); 0.208 |
Usual work setting of respondents | ||
● Other (reference category) | ||
● University or academic institution | −0.70 (− 1.83, 0.45); 0.271 | −0.59 (− 1.76, 0.60); 0.317 |
● Private/contracted research company | −1.03 (− 2.40, 0.40); 0.139 | − 0.74 (− 2.68, 1.20); 0.417 |
IControlER B n = 59 (R 2 = 0.092, p = 0.64) | n = 85 | |
The respondent has been involved with more than 15 trials | 0.88 (− 0.87, 2.60); 0.282 | 0.86 (− 0.81, 2.52); 0.301 |
The respondent has been involved with more than 15 trials that had a DSMB monitoring the trial | − 0.75 (− 2.44, 0.84); 0.356 | −0.87 (− 2.25, 0.51); 0.214 |
The respondent has been involved with more than 15 trials that had some form of private industry sponsorship | 0.62 (− 0.89, 1.78); 0.441 | 0.73 (− 0.93, 2.40); 0.372 |
Primary profession by training | ||
● Other (reference category) | ||
● Mathematician/statistician/biostatistician | 1.44 (−1.88, 5.67); 0.329 | 1.05 (−0.57, 2.67); 0.202 |
● Methodological scientist/research methodologist | 0.96 (−1.91, 4.64); 0.534 | 0.45 (− 1.45, 2.34); 0.641 |
Usual work setting of respondents | ||
● Other (reference category) | ||
● University or academic institution | 0.27 (−1.72, 2.09); 0.762 | 0.14 (−0.98, 1.26); 0.807 |
● Private/contracted research company | 0.17 (−1.89, 2.61); 0.871 | 0.086 (− 1.59, 1.76); 0.919 |
ACP C n = 51 (R2 = 0.23, p = 0.11) | n = 77 | |
The respondent has been involved with more than 15 trials | −0.68 (− 2.18, 0.67); 0.411 | −0.58 (− 1.99, 0.83); 0.410 |
The respondent has been involved with more than 15 trials that had a DSMB monitoring the trial | − 0.53 (− 2.39, 1.35); 0.515 | − 0.27 (− 1.48, 0.94); 0.665 |
The respondent has been involved with more than 15 trials that had some form of private industry sponsorship | 2.35 (0.45, 4.05); 0.017 | 1.96 (0.48, 3.44); 0.011 |
Primary profession by training | ||
● Other (reference category) | ||
● Mathematician/statistician/biostatistician | 0.52 (−1.35, 2.99); 0.614 | −0.096 (− 1.54, 1.35); 0.896 |
● Methodological scientist/research methodologist | 1.64 (−0.80, 5.10); 0.279 | 0.78 (− 1.36, 2.92); 0.466 |
Usual work setting of respondents | ||
● Other (reference category) | ||
● University or academic institution | 1.21 (−1.07, 4.32); 0.335 | 0.96 (− 0.78, 2.69); 0.259 |
● Private/contracted research company | 0.44 (− 2.07, 3.58); 0.779 | 0.235 (−1.84, 2.31); 0.815 |
UCP B n = 60 (R2 = 0.051, p = 0.90) | n = 82 | |
The respondent has been involved with more than 15 trials | 0.10 (−1.78, 2.02); 0.906 | 0.07 (− 1.48, 1.61); 0.933 |
The respondent has been involved with more than 15 trials that had a DSMB monitoring the trial | −0.32 (− 2.10, 1.48); 0.738 | −0.068 (− 1.64, 1.51); 0.932 |
The respondent has been involved with more than 15 trials that had some form of private industry sponsorship | 0.22 (− 1.58, 1.88); 0.780 | 0.063 (− 1.38, 1.51); 0.932 |
Primary profession by training | ||
● Other (reference category) | ||
● Mathematician/statistician/biostatistician | 0.060 (−2.28, 2.29); 0.955 | −0.55 (− 2.50, 1.39); 0.575 |
● Methodological scientist/research methodologist | 1.45 (−1.04, 4.26); 0.256 | 0.86 (−1.67, 3.40); 0.497 |
Usual work setting of respondents | ||
● Other (reference category) | ||
● University or academic institution | 1.00 (−1.21,,3.20); 0.405 | 1.04 (−0.45, 2.53); 0.169 |
● Private/contracted research company | 1.02 (−2.06, 4.34); 0.508 | 1.15 (−0.89, 3.20); 0.265 |