Fig. 2From: Aerobic exercise program with or without motor complexity as an add-on to the pharmacological treatment of depression – study protocol for a randomized controlled trialStudy design. First 4 weeks, the recruitment and initial test. For 24 weeks, the intervention period – training. Final 2 weeks, the Final tests. Visit 1 (V1): Consent form, Mini International Neuropsychiatric Interview (MINI), MADRS, number of depressive episodes in life, medicine dosage in the last 3 months (necessary clinical adjustments), and anamnesis. Visit 2 (V2): Questionnaire of cognition function, suicidal ideation behavior and sleep; Visit 3 (V3): Blood sample, functional tests, and accelerometer (sleep); Visit 4 (V4): functional tests. Visit 5 (V5): cardiorespiratory parameters; Visit 6 (V6): MRI of the brain and sleep quality (physical activity). After 24 weeks of intervention, all of the experimental groups will be reassessed at visit 7 to visit 11 (V7 to V11). V7: MRI of the brain and accelerometer (sleep); V8: blood sample; V9: MADRS, number of depressive episodes and medicine dosage; V10: Questionnaire of Cognition function, suicidal ideation behavior, sleep; V11: Functional tests and accelerometer (physical activity). At the end of the study, patient treatment costs will be estimated consulting the medical records of each patient. HC hip circumference, WC waist circumferenceBack to article page