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Table 4 Illustrative examples of prospective trial registration, retrospective trial registration, and retrospective registration after initial primary outcome ascertainment

From: Adherence to the International Committee of Medical Journal Editors’ (ICMJE) prospective registration policy and implications for outcome integrity: a cross-sectional analysis of trials published in high-impact specialty society journals

Reference Registration no. Registration date Enrollment start Registration delay Registered primary outcome (time frame) Registration timing
J Am Soc Nephrol. 2010 Jun;21(6):1052–61. NCT00426153 1/22/2007 1/31/2007 N/A Percentage change in liver volume (12 months) Prospective
J Allergy Clin Immunol. 2015 Mar;135(3):670–5.e3. NTR2205 2/8/2010 1/1/2010 1 month Induced sputum neutrophil and eosinophil percentage counts (9 weeks) Retrospective
J Allergy Clin Immunol. 2015 Apr;135(4):922–29.e6. NCT02024659 12/27/2013 9/30/2010 39 months Nasal polyp size (2 weeks) Retrospective (after initial primary outcome ascertainment)